Saturday, January 4, 2025

Baby Sling Warning

Baby Sling
A medical examiner issued a warning about the risks from the "babywearing" trend after a six-week-old boy died while being breastfed hands-free in a sling.

James Alderman, known as Jimmy, was in the baby carrier while his mother moved around their home at the time of his death.

He was in an unsafe position and after five minutes his mother realised he had collapsed, an inquest heard. Resuscitation began straight away, but the baby sadly died in hospital three days later.

Lydia Brown, Senior Coroner for West London, has warned that there is "insufficient information" for parents about the safe positioning of young babies in carriers, particularly when it comes to breastfeeding.

Copies of her "Prevention of Future Deaths Report" were sent to sling manufacturer Beco and Madeleine Boot, a babywearing teacher, as well as the NHS and the Department for Health.

Brown has called for industry standards promoting the safe use of slings and warnings about their risks because there is a danger that young babies could suffocate.

"Babywearing" is a popular phenomenon, worth more than a billion dollars globally, where a child is strapped into a harness or wrapped in a sling so they can be carried by a parent hands-free.

Supporters of the technique say it is practical and helps babies bond with their parents through close contact.

However, critics warn of the risk of suffocation because babies cannot lift their own heads if incorrectly positioned. This risk is increased for babies who are premature or have a low birth weight.

An inquest heard that Jimmy died on 11 October 2023 after being accidentally suffocated.

The baby, who was six weeks and six days old when he died, was feeling well other than having a slight cold.

Thursday, January 2, 2025

Korean Researchers Found A Way To Turn Cancer Cells To Normal

Cancer Cells
There is a trailblazing advancement happening right now in cancer therapy as researchers at Korea Advanced Institute of Science and Technology (KAIST) have developed a technology that transforms colon cancer cells into normal-like cells without destroying them.

This innovative approach, which is being spearheaded led by Professor Kwang-Hyun Cho of the Department of Bio and Brain Engineering, represents a significant departure from traditional cancer treatments that rely on killing cancer cells, often leading to severe side effects and risks of recurrence.

"The fact that cancer cells can be converted back to normal cells is an astonishing phenomenon. This study proves that such reversion can be systematically induced," Cho remarked.

In the introduction to their paper, the researchers detail how research in acute myeloid leukemia, breast cancer, and hepatocellular carcinoma has shown that encouraging tumor cells to differentiate or trans-differentiate can achieve this reversal.

However, identifying the key regulators responsible for driving these processes remains a challenge. If these regulators from normal cell differentiation can be pinpointed and applied to cancerous ones, they could offer a promising alternative to current cancer treatments.

Conventional cancer treatments focus on eradicating cancer cells. While effective in many cases, this method faces two critical challenges: the potential for cancer cells to develop resistance and return, and the collateral damage to healthy cells, resulting in debilitating side effects.

The KAIST team has taken a radically different approach by targeting the root causes of cancer development. Their research hinges on the idea that cancer cells, during their transformation from normal cells, regress along the differentiation trajectory—the process by which normal cells mature into specific functional types.

To tackle this, the researchers created a digital twin of the gene network involved in the differentiation trajectory of normal cells. This computational model allowed them to simulate and analyze the intricate gene interactions that regulate cell differentiation.

Through their simulations, the team pinpointed master molecular switches capable of steering cells from colon cancer back into a normal-like state. These findings were then validated through molecular experiments, cellular studies, and animal trials, demonstrating the effectiveness of this approach.

Wednesday, January 1, 2025

Djokovic Hits At 'Double Standards' In Tennis

Djokovic
Tennis legend Novak Djokovic has hit out at perceived double standards in tennis doping investigations as he claimed the sport is being "kept in the dark" over the Jannik Sinner case.

Djokovic, now being coached by Sir Andy Murray, added his voice to concerns after Nick Kyrgios said this week that cases involving grand-slam tournament winners Sinner and Iga Swiatek were "disgusting" for tennis.

The International Tennis Integrity Agency (ITIA) charged both Sinner and former women’s world No 1 Swiatek with anti-doping breaches earlier in the year.

Djokovic, eyeing a record 25th major title at next month’s Australian Open, teams up Kyrgios in doubles at the Brisbane International this week and shares some of his worries amid the cloud above their sport.

"I’m not questioning whether [Sinner] took the banned substance intentionally or not," Djokovic said at a press conference in Brisbane last 29 December. "We’ve had plenty of players in the past and currently under suspension for not even testing positive to banned substances.

"Some players with lower rankings waiting for their case to be resolved for over a year. I’ve been really frustrated ... to see we’ve been kept in the dark for at least five months [on the Sinner case]."

Sinner tested positive twice for an anabolic steroid in March but avoided a ban after the ITIA ruled he was not at fault. The World Anti-Doping Agency has appealed against the decision. Swiatek accepted a one-month suspension in November after testing positive for the banned substance trimetazidine.

Djokovic took aim at a lack of transparency from tennis authorities in general regarding doping breaches. "The ATP hasn’t really talked in depth about it. Why have they kept that case away from the public? We see Simona Halep’s case on the WTA Tour, now Iga Swiatek's case," Djokovic said.

"It's not a good image for our sport. I'm just questioning the way the system works and why certain players aren’t treated the same as others. Maybe some ranking reasons are behind it, or some players have more financial backing and stronger legal teams to tackle these cases."

Djokovic is the top seed in the Brisbane International this week, making his first appearance at the event since 2009. He spoke separately of it being "strange" to have his former rival Murray working as his coach but he believes he will benefit from the Scot’s "fresh look" at his game.